Spred2 Gene Summary [Rat]
Predicted to enable protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Predicted to be involved in negative regulation of cell differentiation and regulation of signal transduction. Predicted to act upstream of or within negative regulation of MAPK cascade. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spred2 |
| Official Name | sprouty-related, EVH1 domain containing 2 [Source:RGD Symbol;Acc:1309304] |
| Ensembl ID | ENSRNOG00000004888 |
| Bio databases IDs | |
| Aliases | sprouty-related, EVH1 domain containing 2 |
| Synonyms | C79158, NS14, sprouty-related EVH1 domain containing 2, sprouty-related, EVH1 domain containing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spred2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stem cell factor receptor binding
- protein serine/threonine kinase inhibitor
- protein kinase binding
- protein binding
- Pleckstrin homology-like domain
- cytokine
- zDHHC ankyrin repeat binding domain
- Sprouty protein (Spry)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Alzheimer disease
- rheumatoid arthritis
- systemic lupus erythematosus
- Noonan syndrome
- non-insulin-dependent diabetes mellitus
- dwarfism
- suicide attempt
- bleeding
- gout
role in cell
- phosphorylation in
- binding in
- expression in
- quantity
- activation in
- production in
- differentiation
- number
- transcription in
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Plasma Membrane
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spred2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of epithelial to mesenchymal transition
- regulation of protein deacetylation
- negative regulation of MAPK cascade
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- transport vesicle membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein serine/threonine kinase inhibitor activity
- protein binding
- stem cell factor receptor binding