Rrm2b Gene Summary [Rat]
Predicted to enable identical protein binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in response to amine. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrm2b |
| Official Name | ribonucleotide reductase regulatory TP53 inducible subunit M2B [Source:RGD Symbol;Acc:1306045] |
| Ensembl ID | ENSRNOG00000025454 |
| Bio databases IDs | |
| Aliases | ribonucleotide reductase regulatory TP53 inducible subunit M2B |
| Synonyms | MGC42116, MTDPS8A, MTDPS8B, P53R2, RCDFRD, Ribonucleotide Reductase M2 B (TP53 Inducible), ribonucleotide reductase regulatory TP53 inducible subunit M2B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rrm2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonucleoside-diphosphate reductase
- nuclear localization sequence
- enzyme
- protein binding
- identical protein binding
- Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Pathways
Biological processes and signaling networks where the Rrm2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- neoplasia
- Langerhans cell histiocytosis
- Waldenström macroglobulinemia
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- cardiac fibrosis
- acute myeloid leukemia
- cervical squamous cell carcinoma
- chronic lymphocytic leukemia
role in cell
- expression in
- growth
- apoptosis
- cell death
- degradation in
- survival
- function
- homologous recombination repair in
- mutagenesis
- immortalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rrm2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside diphosphate metabolic process
- DNA repair
- deoxyribonucleoside triphosphate metabolic process
- 2'-deoxyribonucleotide biosynthetic process
- response to amine stimulus
- deoxyribonucleotide biosynthetic process
- mitochondrial DNA replication
- DNA synthesis involved in DNA repair
- renal system process
- response to oxidative stress
- kidney development
- positive regulation of G0 to G1 transition
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- ribonucleoside-diphosphate reductase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- metal ion binding