Rrm2b

Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitochondrial DNA replication and positive regulation of G0 to G1 transition. Acts upstream of or within several processes, including DNA repair; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rrm2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Rrm2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rrm2b gene, providing context for its role in the cell.