Rrm2b Gene Summary [Mouse]
Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitochondrial DNA replication and positive regulation of G0 to G1 transition. Acts upstream of or within several processes, including DNA repair; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrm2b |
| Official Name | ribonucleotide reductase M2 B (TP53 inducible) [Source:MGI Symbol;Acc:MGI:2155865] |
| Ensembl ID | ENSMUSG00000022292 |
| Bio databases IDs | |
| Aliases | ribonucleotide reductase M2 B (TP53 inducible) |
| Synonyms | MGC42116, MTDPS8A, MTDPS8B, P53R2, RCDFRD, Ribonucleotide Reductase M2 B (TP53 Inducible), ribonucleotide reductase regulatory TP53 inducible subunit M2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rrm2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonucleoside-diphosphate reductase
- nuclear localization sequence
- enzyme
- protein binding
- identical protein binding
- Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Pathways
Biological processes and signaling networks where the Rrm2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- neoplasia
- Langerhans cell histiocytosis
- Waldenström macroglobulinemia
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- cardiac fibrosis
- acute myeloid leukemia
- cervical squamous cell carcinoma
- chronic lymphocytic leukemia
phenotypes
- abnormal blood homeostasis
- abnormal compact bone morphology
- abnormal coronary artery morphology
- abnormal glomerular capillary endothelium morphology
- abnormal glomerular capillary morphology
- abnormal glomerular capsule parietal layer morphology
- abnormal glomerular endothelium fenestra morphology
- abnormal glomerular mesangium morphology
- abnormal kidney physiology
- abnormal liver morphology
- abnormal mesenteric lymph node morphology
- abnormal podocyte morphology
- abnormal renal glomerular capsule morphology
- abnormal renal glomerulus basement membrane morphology
- abnormal renal glomerulus morphology
- abnormal renal tubule epithelium morphology
- abnormal renal tubule morphology
- abnormal sciatic nerve morphology
- abnormal submandibular gland morphology
- abnormal urine homeostasis
- cardiac fibrosis
- cortical renal glomerulopathies
- decreased circulating alkaline phosphatase level
- decreased circulating glucose level
- decreased circulating serum albumin level
- decreased glomerular capillary number
- decreased hematocrit
- decreased hemoglobin content
- decreased lean body mass
- decreased spleen white pulp amount
- decreased total body fat amount
- dilated renal tubules
- enlarged kidney
- glomerulosclerosis
- hyperlipidemia
- increased blood urea nitrogen level
- increased circulating cholesterol level
- increased circulating creatinine level
- increased circulating phosphate level
- increased circulating triglyceride level
- increased glomerular capsule space
- increased kidney apoptosis
- increased kidney cell proliferation
- increased renal glomerulus basement membrane thickness
- increased renal tubule apoptosis
- increased urine protein level
- kidney failure
- muscular atrophy
- pale kidney
- podocyte foot process effacement
- podocyte hypertrophy
- postnatal growth retardation
- premature death
- proximal convoluted tubule brush border loss
- renal glomerulus fibrosis
- renal tubular necrosis
- renal tubule atrophy
- skeletal muscle atrophy
- slow postnatal weight gain
- spleen atrophy
- thrombocytosis
- thymus atrophy
- thymus cortex hypoplasia
role in cell
- expression in
- growth
- apoptosis
- cell death
- degradation in
- survival
- function
- homologous recombination repair in
- mutagenesis
- immortalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rrm2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside diphosphate metabolic process
- DNA repair
- deoxyribonucleoside triphosphate metabolic process
- 2'-deoxyribonucleotide biosynthetic process
- response to amine stimulus
- deoxyribonucleotide biosynthetic process
- mitochondrial DNA replication
- DNA synthesis involved in DNA repair
- renal system process
- response to oxidative stress
- kidney development
- positive regulation of G0 to G1 transition
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- ribonucleoside-diphosphate reductase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- metal ion binding