Lmnb2 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in lamin filament and nuclear membrane. Predicted to be active in nuclear lamina. Human ortholog(s) of this gene implicated in autosomal dominant primary microcephaly 27; partial lipodystrophy; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmnb2 |
| Official Name | lamin B2 [Source:RGD Symbol;Acc:1563803] |
| Ensembl ID | ENSRNOG00000025742 |
| Bio databases IDs | |
| Aliases | lamin B2 |
| Synonyms | EPM9, LAMB2, lamin B2, Lamin B3, LMN2, MCPH27, RGD1563803 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lmnb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- structural constituent of cytoskeleton
- Lamin Tail Domain
- Intermediate filament protein
- protein binding
- identical protein binding
- Apolipoprotein A1/A4/E domain
Pathways
Biological processes and signaling networks where the Lmnb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant primary microcephaly 27
- aortic valve calcification
- major depression
- microcephaly
- familial partial lipodystrophy
- acquired partial lipodystrophy
- respiratory failure
- progressive myoclonic epilepsy type 9
- postmenopausal osteoporosis
role in cell
- cell death
- number
- migration
- proliferation
- differentiation
- rupture
- shape change
- function
- disruption
- volume
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- pH resistant lipid raft fraction
- nucleolar periphery
- nuclear pores
- inner nuclear membrane
- nuclear rim
- nuclear envelope
- nuclear lamina
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lmnb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear pore localization
- nuclear envelope organization
- cytoskeleton organization
- heterochromatin assembly
- nuclear migration
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- intermediate filament
- nuclear lamina
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of cytoskeleton