Cfp Gene Summary [Rat]
Predicted to be involved in complement activation, alternative pathway. Predicted to be located in cytoplasmic side of Golgi membrane; extracellular space; and secretory granule. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfp |
| Official Name | complement factor properdin [Source:RGD Symbol;Acc:1594557] |
| Ensembl ID | ENSRNOG00000025811 |
| Bio databases IDs | |
| Aliases | complement factor properdin |
| Synonyms | BCFG, BFD, complement factor properdin, PFC, PFD, PROPERDIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cfp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- thrombospondin type 1 repeat
- protein binding
- Spondin-like TSP1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- arthritis
- COVID-19
- epithelial cancer
- liver cancer
- properdin deficiency
- type III properdin deficiency
- sepsis
- hepatocellular carcinoma
- organismal death
role in cell
- expression in
- proliferation
- cell viability
- binding
- formation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
- endoplasmic reticulum lumen
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cfp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- complement activation, alternative pathway
- immune response
- defense response to bacterium
- positive regulation of immune response
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- specific granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding