Gne Gene Summary [Rat]
Enables N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in CMP-N-acetylneuraminate biosynthetic process; N-acetylneuraminate biosynthetic process; and glycosylation. Is active in cytosol. Human ortholog(s) of this gene implicated in GNE myopathy; sialuria; and thrombocytopenia. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gne |
| Official Name | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [Source:RGD Symbol;Acc:69239] |
| Ensembl ID | ENSRNOG00000014365 |
| Bio databases IDs | |
| Aliases | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase |
| Synonyms | 2310066H07Rik, DMRV, GLCNE, glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, IBM2, LOC100503899, NM, THC12, Uae1, Udp n acetylglucosamine 2 epimerase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gne often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- glycosyltransferase family 1 and related proteins with GTB topology
- N-acylmannosamine kinase
- UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
- UDP-N-acetylglucosamine 2-epimerase
- ROK family
- UDP-N-acetylglucosamine 2-epimerase [Cell wall/membrane/envelope biogenesis]
- protein binding
- enzyme
- ROK family protein (putative glucokinase)
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Nonaka myopathy
- liver cancer
- vacuolar neuromyopathy
- hepatocellular carcinoma
- proteinuria
- sialic acid storage disease
- hereditary disorder
- vacuolar myopathy
- Lynch syndrome
role in cell
- expression in
- apoptosis
- proliferation
- cleavage
- phagocytosis
- phagocytosis by
- effacement
- biosynthesis in
- anoikis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gne gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UDP-N-acetylglucosamine metabolic process
- N-acetylglucosamine biosynthetic process
- carbohydrate phosphorylation
- N-acetylneuraminate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- N-acylmannosamine kinase activity
- UDP-N-acetylglucosamine 2-epimerase activity
- hydrolase activity, hydrolyzing O-glycosyl compounds