Rbms3 Gene Summary [Rat]
Predicted to enable mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be involved in defense response to tumor cell; negative regulation of canonical Wnt signaling pathway; and regulation of gene expression. Predicted to act upstream of or within positive regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Orthologous to human RBMS3 (RNA binding motif single stranded interacting protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbms3 |
| Official Name | RNA binding motif, single stranded interacting protein 3 [Source:RGD Symbol;Acc:1588240] |
| Ensembl ID | ENSRNOG00000025881 |
| Bio databases IDs | |
| Aliases | RNA binding motif, single stranded interacting protein 3 |
| Synonyms | 6720477E09RIK, 8430436O14RIK, LOC108353600, RNA binding motif, single stranded interacting protein, RNA binding motif single stranded interacting protein 3, RNA binding motif, single stranded interacting protein 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbms3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- poly(A) binding protein
- poly(U) binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- preeclampsia
- colorectal cancer
- COVID-19
- acute myeloid leukemia
- Alzheimer disease
- refractive error
- Parkinson disease
- major depression
role in cell
- invasion by
- migration
- differentiation
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rbms3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of gene expression
- defense response to tumor cell
- positive regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR AU-rich region binding
- poly(A) RNA binding
- poly(U) RNA binding
- mRNA 3'-UTR binding