Nipbl Gene Summary [Rat]
Predicted to enable several functions, including chromo shadow domain binding activity; cohesin loader activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including chromosome organization; embryonic morphogenesis; and reproductive structure development. Predicted to act upstream of or within several processes, including embryonic cranial skeleton morphogenesis; fat cell differentiation; and positive regulation of ossification. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of Scc2-Scc4 cohesin loading complex and integrator complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome and Cornelia de Lange syndrome 1. Orthologous to human NIPBL (NIPBL cohesin loading factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nipbl |
| Official Name | NIPBL, cohesin loading factor [Source:RGD Symbol;Acc:1306393] |
| Ensembl ID | ENSRNOG00000056907 |
| Bio databases IDs | |
| Aliases | NIPBL, cohesin loading factor |
| Synonyms | 4921518A06RIK, 4933421G18RIK, C79399, CDLS, CDLS1, IDN3, IDN3-B, LOC681423, NIPBL cohesin loading factor, NIPBL, cohesin loading factor, Scc2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nipbl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- binding protein
- HEAT repeat associated with sister chromatid cohesion
- transcription co-repressor
- histone deacetylase binding
- protein domain specific binding
- chromatin binding
- enzyme
- Sister chromatid cohesion protein 2 and homologs
- protein binding
- Intracellular hyaluronan-binding protein 4 N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- Wilms tumorigenesis
- precursor B-cell acute lymphoblastic leukemia
- metastasis
- Cornelia de Lange syndrome type 1
- hereditary disorder
- myoclonus
- idiopathic scoliosis
- mental retardation
- organismal death
role in cell
- expression in
- migration
- differentiation
- invasion by
- DNA damage response
- ossification by
- migration by
- mitotic entry in
- remodeling
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nipbl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- external genitalia morphogenesis
- gall bladder development
- protein localization
- outflow tract morphogenesis
- embryonic digestive tract morphogenesis
- fat cell differentiation
- uterus morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of multicellular organism growth
- face morphogenesis
- regulation of developmental growth
- regulation of hair cycle
- negative regulation of transcription from RNA polymerase II promoter
- sensory perception of sound
- chromatin remodeling
- heart morphogenesis
- cognition
- digestive tract development
- somatic stem cell maintenance
- forelimb morphogenesis
- embryonic forelimb morphogenesis
- positive regulation of neuron migration
- maintenance of mitotic sister chromatid cohesion
- mitotic sister chromatid cohesion
- establishment of mitotic sister chromatid cohesion
- regulation of embryonic development
- developmental growth
- brain development
- response to DNA damage stimulus
- positive regulation of ossification
- embryonic viscerocranium morphogenesis
- cellular response to X-ray
- eye morphogenesis
- metanephros development
- ear morphogenesis
- mitotic sister chromatid segregation
- establishment of protein localization to chromatin
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- cytosol
- chromatin
- SMC loading complex
- nucleoplasm
- integrator complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- chromo shadow domain binding
- mediator complex binding
- chromatin binding