Hk3 Gene Summary [Rat]

Enables enzyme binding activity; hexokinase activity; and hormone binding activity. Involved in fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; and negative regulation of hydrogen peroxide-mediated programmed cell death. Part of protein-containing complex. Orthologous to human HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Hk3
Official Name
hexokinase 3 [Source:RGD Symbol;Acc:2798]
Ensembl ID
ENSRNOG00000026235
Bio databases IDs NCBI: 25060 Ensembl: ENSRNOG00000026235
Aliases hexokinase 3
Synonyms hexokinase 3, HK-III, HXK3, RNU73859
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • kinase
  • hormone binding
  • regulatory domain
  • catalytic domain
  • enzyme binding
  • PLN02914
  • glucokinase
  • protein binding
  • fructokinase
  • hexokinase
  • ASKHA_ATPase-like

Pathways

Biological processes and signaling networks where the Hk3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • hepatocellular carcinoma
  • renal clear cell adenocarcinoma
  • sepsis
  • septic shock
  • liver cancer
  • epithelial cancer
  • organismal death
  • autoimmune disease
  • renal clear cell cancer
regulated by
regulates
  • PRKN
  • reactive oxygen species
  • lactic acid
  • D-glucose
  • glucose-6-phosphate
  • fructose-6-phosphate
role in cell
  • growth
  • proliferation
  • cell viability
  • migration
  • activation
  • differentiation
  • M1 polarization
  • M2 polarization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • secretory granule lumen
  • ficolin-1-rich granule lumen
  • Extracellular Space
  • Nucleus
  • cytosol
  • plasma
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Hk3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • glucose 6-phosphate metabolic process
  • cellular glucose homeostasis
  • glycolysis
  • fructose 6-phosphate metabolic process
  • carbohydrate phosphorylation
  • glucose metabolic process

Cellular Component

Where in the cell the gene product is active
  • mitochondrion
  • cytosol
  • secretory granule lumen
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • glucose binding
  • ATP binding
  • protein binding
  • glucokinase activity
  • hexokinase activity
  • fructokinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.