HK3 Gene Summary [Human]
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
Details
| Type | Retained Intron |
| Official Symbol | HK3 |
| Official Name | hexokinase 3 [Source:HGNC Symbol;Acc:HGNC:4925] |
| Ensembl ID | ENSG00000160883 |
| Bio databases IDs | |
| Aliases | hexokinase 3 |
| Synonyms | hexokinase 3, HK-III, HXK3, RNU73859 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- hormone binding
- regulatory domain
- catalytic domain
- enzyme binding
- PLN02914
- glucokinase
- protein binding
- fructokinase
- hexokinase
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the HK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- renal clear cell adenocarcinoma
- sepsis
- septic shock
- liver cancer
- epithelial cancer
- organismal death
- autoimmune disease
- renal clear cell cancer
regulates
- PRKN
- reactive oxygen species
- lactic acid
- D-glucose
- glucose-6-phosphate
- fructose-6-phosphate
role in cell
- growth
- proliferation
- cell viability
- migration
- activation
- differentiation
- M1 polarization
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucose 6-phosphate metabolic process
- cellular glucose homeostasis
- glycolysis
- fructose 6-phosphate metabolic process
- carbohydrate phosphorylation
- glucose metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glucose binding
- ATP binding
- protein binding
- glucokinase activity
- hexokinase activity
- fructokinase activity