Igfbp4 Gene Summary [Rat]
Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igfbp4 |
| Official Name | insulin-like growth factor binding protein 4 [Source:RGD Symbol;Acc:2875] |
| Ensembl ID | ENSRNOG00000010635 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor binding protein 4 |
| Synonyms | BP-4, DEB2, HT29-IGFBP, IBP-4, IGF-BP, insulin-like growth factor binding protein 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Igfbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TY
- insulin-like growth factor binding
- protein binding
- receptor binding
- Insulin-like growth factor binding protein
- cleavage site
Pathways
Biological processes and signaling networks where the Igfbp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- hepatocellular carcinoma
- organismal death
- epithelial cancer
- liver cancer
- dermatomyositis
- survival
- streptozotocin-induced diabetic nephropathy
- serous ovarian cancer
role in cell
- apoptosis
- expression in
- proliferation
- growth
- migration
- colony formation
- adipogenesis in
- steroidogenesis in
- abnormal morphology
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Igfbp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- MAPK cascade
- regulation of glucose metabolic process
- signal transduction
- regulation of cell growth
- type B pancreatic cell proliferation
- positive regulation of MAPK cascade
- response to organic cyclic compound
- regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of insulin-like growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding