Akap9 Gene Summary [Rat]
Enables protein kinase A regulatory subunit binding activity. Involved in negative regulation of adenylate cyclase activity and response to electrical stimulus. Located in dendritic branch; neuronal cell body; and synaptic membrane. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in long QT syndrome 11. Orthologous to human AKAP9 (A-kinase anchoring protein 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap9 |
| Official Name | A-kinase anchoring protein 9 [Source:RGD Symbol;Acc:620833] |
| Ensembl ID | ENSRNOG00000026319 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 9 |
| Synonyms | 5730481H23Rik, AKAP350, AKAP450, A-kinase anchoring protein 9, A kinase anchor protein 9, CG-NAP, G1-448-15, Gisp, HYPERION, LQT11, mei2-5, mKIAA0803, MU-RMS-40.16A, PPP1R45, PRKA9, repro12, YOTIAO |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akap9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- leucine zipper domain
- PP1 binding domain
- casein kinase I delta binding site
- CIP4 binding domain
- chromosome segregation protein SMC, common bacterial type
- ion channel binding
- leucine/Isoleucine zipper domain
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- protein kinase A binding
- exonuclease SbcC
- channel regulator
- Hyaluronan mediated motility receptor N-terminal
- potassium channel regulator
- Myosin tail
- protein binding
- receptor binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- pericentrin homology domain
- Pericentrin-AKAP-450 domain of centrosomal targeting protein
Pathways
Biological processes and signaling networks where the Akap9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- long QT syndrome 11
- long-QT syndrome
role in cell
- phosphorylation in
- quantity
- development
- activation in
- migration
- binding in
- accumulation in
- polymerization
- cell cycle progression
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytocentrum fractions
- soluble fraction
- apical ectoplasmic specialization
- motile cilia
- basal ectoplasmic specialization
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cytoskeleton
- perinuclear region
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- asters
- cytosol
- microsome
- synaptic membrane
- Golgi stacks
- cis Golgi networks
- spindle pole
- nuclear scaffolds
- glial cell projections
- perikaryon
- dendritic branches
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akap9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- microtubule nucleation
- regulation of membrane repolarization
- synaptic transmission
- regulation of ventricular cardiomyocyte membrane repolarization
- protein complex localization
- maintenance of centrosome location
- cellular response to cAMP
- regulation of heart rate by cardiac conduction
- response to electrical stimulus
- positive regulation of microtubule polymerization
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendritic branch
- voltage-gated potassium channel complex
- Golgi apparatus
- synaptic membrane
- neuronal cell body
- Golgi stack
- potassium channel complex
- centrosome
- cytoskeleton
- cis-Golgi network
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein kinase A regulatory subunit binding
- potassium channel regulator activity
- ion channel binding
- receptor binding
- binding, bridging