Krt17 Gene Summary [Rat]
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including hair follicle morphogenesis; intermediate filament organization; and positive regulation of hair follicle development. Predicted to act upstream of or within keratinization and morphogenesis of an epithelium. Predicted to be located in cell periphery; cytoplasm; and intermediate filament cytoskeleton. Predicted to be active in cornified envelope and cytoskeleton. Human ortholog(s) of this gene implicated in ectodermal dysplasia; pachyonychia congenita; and steatocystoma multiplex. Orthologous to human KRT17 (keratin 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt17 |
| Official Name | keratin 17 [Source:RGD Symbol;Acc:1303181] |
| Ensembl ID | ENSRNOG00000026371 |
| Bio databases IDs | |
| Aliases | keratin 17 |
| Synonyms | 39.1, CK-17, K17, Ka17, keratin 17, KRT1-17, PC, PC2, PCHC1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Krt17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- systemic sclerosis
- hyperplasia
- lymphatic neoplasia
- epithelial cancer
- epithelial neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- cervical cancer
- psoriasis
role in cell
- proliferation
- expression in
- formation
- binding in
- growth
- morphology
- migration
- signaling in
- formation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cornified envelope
- intermediate filament cytoskeleton
- cell periphery
- intermediate filaments
- keratin filament networks
- cytosol
- nucleoli
- nuclear scaffolds
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- positive regulation of cell growth
- positive regulation of translation
- hair follicle morphogenesis
- keratinization
- intermediate filament organization
- positive regulation of hair follicle development
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytoskeleton
- keratin filament
- intermediate filament cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity