Naf1 Gene Summary [Rat]
Predicted to enable identical protein binding activity and telomerase RNA binding activity. Predicted to be involved in protein-RNA complex assembly; ribosome biogenesis; and telomerase RNA stabilization. Predicted to act upstream of or within telomerase RNA localization to Cajal body. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of sno(s)RNA-containing ribonucleoprotein complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human NAF1 (nuclear assembly factor 1 ribonucleoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Naf1 |
| Official Name | nuclear assembly factor 1 ribonucleoprotein [Source:RGD Symbol;Acc:1306802] |
| Ensembl ID | ENSRNOG00000026403 |
| Bio databases IDs | |
| Aliases | nuclear assembly factor 1 ribonucleoprotein |
| Synonyms | BC053440, Gm174, nuclear assembly factor 1 ribonucleoprotein, PFBMFT7, RGD1306802 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Naf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Gar1/Naf1 RNA binding region
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- telomere-related pulmonary fibrosis and/or bone marrow failure syndrome type 7
- acute myeloid leukemia
role in cell
- growth
- production in
- morphology
- autophagy by
- biogenesis
- depression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Naf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- box H/ACA snoRNP assembly
- positive regulation of telomere maintenance via telomerase
- ribosome biogenesis
- RNA stabilization
- snoRNA guided rRNA pseudouridine synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- small nucleolar ribonucleoprotein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- telomeric RNA binding