NAF1 Gene Summary [Human]
Enables identical protein binding activity and telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and telomerase holoenzyme complex assembly. Located in nucleoplasm. Part of sno(s)RNA-containing ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NAF1 |
| Official Name | nuclear assembly factor 1 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:25126] |
| Ensembl ID | ENSG00000145414 |
| Bio databases IDs | |
| Aliases | nuclear assembly factor 1 ribonucleoprotein |
| Synonyms | BC053440, Gm174, nuclear assembly factor 1 ribonucleoprotein, PFBMFT7, RGD1306802 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NAF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Gar1/Naf1 RNA binding region
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- telomere-related pulmonary fibrosis and/or bone marrow failure syndrome type 7
- acute myeloid leukemia
role in cell
- growth
- production in
- morphology
- autophagy by
- biogenesis
- depression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NAF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- box H/ACA snoRNP assembly
- positive regulation of telomere maintenance via telomerase
- ribosome biogenesis
- RNA stabilization
- snoRNA guided rRNA pseudouridine synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- small nucleolar ribonucleoprotein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- telomeric RNA binding