Ikzf2 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ikzf2 |
| Official Name | IKAROS family zinc finger 2 [Source:RGD Symbol;Acc:1308686] |
| Ensembl ID | ENSRNOG00000027430 |
| Bio databases IDs | |
| Aliases | IKAROS family zinc finger 2 |
| Synonyms | A730095J18Rik, ANF1A2, HELIOS, IKAROS family zinc finger 2, Zfpn1a2, ZNF1A2, ZNFN1A2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ikzf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- DNA binding domain
- Zinc-finger double domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- systemic lupus erythematosus
- adult T cell leukemia
- neoplasia
- non-insulin-dependent diabetes mellitus
- lung squamous cell carcinoma
- squamous cell lung cancer
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- growth
- proliferation
- survival
- production in
- upregulation in
- conversion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- intracellular space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ikzf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding