Tnfsf4 Gene Summary [Rat]
Enables tumor necrosis factor receptor superfamily binding activity. Involved in T cell proliferation; positive regulation of activated T cell proliferation; and positive regulation of interleukin-2 production. Located in cell surface. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human TNFSF4 (TNF superfamily member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf4 |
| Official Name | TNF superfamily member 4 [Source:RGD Symbol;Acc:619816] |
| Ensembl ID | ENSRNOG00000002968 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 4 |
| Synonyms | ATH1, CD134L, CD252, GP34, OX-40L, OX40 LIGAND, OX4OL, TNF superfamily member 4, TNLG2B, tumor necrosis factor (ligand) superfamily, member 4, tumour necrosis factor (ligand) superfamily, member 4, TXGP1, Txgp1l |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfsf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- extracellular domain
- TNF homology domain
- tumor necrosis factor receptor binding
- TNF
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Tnfsf4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- arthritis
- systemic lupus erythematosus
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- multiple sclerosis
- asthma
- COVID-19
role in cell
- expression in
- apoptosis
- accumulation
- activation in
- activation
- binding in
- proliferation
- binding
- adhesion
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfsf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- response to virus
- cellular response to prostaglandin E stimulus
- negative regulation of T-helper 1 cell differentiation
- positive regulation of type 2 immune response
- inflammatory response
- defense response to nematode
- negative regulation of regulatory T cell differentiation
- positive regulation of B cell activation
- immune response
- positive regulation of CD4-positive, alpha-beta T cell differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of alpha-beta T cell proliferation
- positive regulation of interferon-gamma production
- T-helper 2 cell activation
- positive regulation of immunoglobulin production
- response to nitrogen dioxide
- regulation of adaptive immune response
- positive regulation of chemokine production
- positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
- negative regulation of interferon-gamma production
- negative regulation of interleukin-17 production
- positive regulation of CD4-positive, alpha beta T cell costimulation
- signal transduction
- positive regulation of inflammatory response
- positive regulation of T-helper 2 cell differentiation
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of T cell proliferation
- positive regulation of immunoglobulin mediated immune response
- memory T cell activation
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- cellular response to lipopolysaccharide
- positive regulation of memory T cell differentiation
- acute inflammatory response
- positive regulation of T cell cytokine production
- regulation of inflammatory response
- positive regulation of interleukin-6 production
- positive regulation of interleukin-10 production
- positive regulation of cytokine production
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- tumor necrosis factor receptor superfamily binding
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding