Batf Gene Summary [Rat]

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; hemopoiesis; and positive regulation of macromolecule biosynthetic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human BATF (basic leucine zipper ATF-like transcription factor). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Batf
Official Name
basic leucine zipper ATF-like transcription factor [Source:RGD Symbol;Acc:1304923]
Ensembl ID
ENSRNOG00000008588
Bio databases IDs NCBI: 299206 Ensembl: ENSRNOG00000008588
Aliases basic leucine zipper ATF-like transcription factor
Synonyms basic leucine zipper ATF-like transcription factor, basic leucine zipper transcription factor, ATF-like, BATF1, SFA-2
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Batf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • transcription regulator
  • transcription factor binding domain
  • nucleic acid binding
  • double-stranded DNA binding
  • Basic region leucine zipper
  • protein binding
  • sequence-specific DNA binding
  • bZIP
  • transcription factor activity
  • basic region leucin zipper

Pathways

Biological processes and signaling networks where the Batf gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • inflammatory disorder
  • pneumonitis
  • idiopathic scoliosis
  • colitis
  • diabetic nephropathy
  • Crohn disease
  • exhaustion
  • experimental autoimmune encephalomyelitis
  • multiple sclerosis
  • neonatal late-onset sepsis
regulated by
regulates
role in cell
  • expression in
  • production in
  • proliferation
  • phosphorylation in
  • differentiation
  • binding in
  • migration
  • quantity
  • number
  • growth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • nucleoplasm
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Batf gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • hemopoietic stem cell differentiation
  • response to DNA damage stimulus
  • positive regulation of transcription from RNA polymerase II promoter
  • lymphoid progenitor cell differentiation
  • regulation of transcription from RNA polymerase II promoter
  • defense response to protozoan
  • regulation of T-helper 17 cell differentiation
  • T-helper 2 cell differentiation
  • myeloid dendritic cell differentiation
  • T-helper 17 cell lineage commitment
  • DNA damage response, signal transduction by p53 class mediator
  • T-helper 17 cell differentiation
  • positive regulation of cytokine production
  • isotype switching

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • chromatin
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • sequence-specific DNA binding transcription factor activity
  • protein binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  • sequence-specific DNA binding
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.