Adamts7 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; collagen fibril organization; and skeletal system development. Predicted to be located in cell surface. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts7 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 7 [Source:RGD Symbol;Acc:1306713] |
| Ensembl ID | ENSRNOG00000028036 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 7 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 7, ADAM metallopeptidase with thrombospondin type 1 motif, 7, ADAMTS7B, COMPase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- thrombospondin-1 motif
- MAPK-interacting and spindle-stabilising protein-like
- catalytic domain
- ADAMTS cysteine-rich domain 2
- metalloprotease domain
- ADAMTS cysteine-rich domain
- peptidase
- protein binding
- metallopeptidase
- ADAM-TS Spacer 1
- ZnMc
- spacer domain
- Metallo-peptidase family M12B Reprolysin-like
- Reprolysin (M12B) family zinc metalloprotease
- disintegrin-like domain
- Spondin-like TSP1 domain
- pro domain
- cysteine rich domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung carcinoma
- lung carcinoma process
- coronary artery disease
- lung adenocarcinoma formation
- angina pectoris
- androgenic alopecia
- heart disease
- rheumatoid arthritis
- cardiovascular disorder
role in cell
- invasion by
- formation
- differentiation
- migration
- organization
- response by
- ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to BMP stimulus
- proteolysis
- extracellular matrix organization
- chondrocyte differentiation
- cellular response to interleukin-1
- cellular response to tumor necrosis factor
- negative regulation of chondrocyte differentiation
- collagen fibril organization
- proteolysis involved in cellular protein catabolic process
- proteoglycan metabolic process
- ossification involved in bone maturation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular matrix
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity
- metallopeptidase activity