Ecm1 Gene Summary [Rat]
Predicted to enable interleukin-2 receptor binding activity and protease binding activity. Predicted to be involved in several processes, including negative regulation of bone mineralization; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within several processes, including regulation of T cell migration; regulation of type 2 immune response; and skeletal system development. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in lipoid proteinosis. Orthologous to human ECM1 (extracellular matrix protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ecm1 |
| Official Name | extracellular matrix protein 1 [Source:RGD Symbol;Acc:620357] |
| Ensembl ID | ENSRNOG00000021166 |
| Bio databases IDs | |
| Aliases | extracellular matrix protein 1 |
| Synonyms | extracellular matrix protein 1, p85, URBWD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ecm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-2 receptor binding
- protease binding
- ligand-binding domain
- Extracellular matrix protein 1 (ECM1)
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Ecm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- epithelial cancer
- inflammatory bowel disease
- experimental autoimmune encephalomyelitis
- lipoid proteinosis of urbach and wiethe
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- hepatocellular carcinoma
role in cell
- production in
- expression in
- activation in
- proliferation
- phosphorylation in
- quantity
- accumulation in
- function
- growth
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- Mitochondria
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ecm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- chondrocyte development
- positive regulation of angiogenesis
- regulation of transcription from RNA polymerase II promoter
- negative regulation of cytokine-mediated signaling pathway
- negative regulation of bone mineralization
- inflammatory response
- regulation of T cell migration
- endochondral bone growth
- ossification
- angiogenesis
- regulation of type 2 immune response
- positive regulation of endothelial cell proliferation
- negative regulation of peptidase activity
- regulation of bone mineralization
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- platelet dense granule lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-2 receptor binding
- protease binding
- extracellular matrix structural constituent