Tnni3k Gene Summary [Rat]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase activity. Predicted to be involved in peptidyl-serine autophosphorylation; regulation of heart contraction; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including TNNI3K (TNNI3 interacting kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnni3k |
| Official Name | TNNI3 interacting kinase [Source:RGD Symbol;Acc:727908] |
| Ensembl ID | ENSRNOG00000028225 |
| Bio databases IDs | |
| Aliases | TNNI3 interacting kinase |
| Synonyms | CARK, CCDD, D830019J24Rik, TNNI3 interacting kinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnni3k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Ankyrin repeats (many copies)
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Ankyrin repeats (3 copies)
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- cardiac conduction disease with or without dilated cardiomyopathy
- insomnia
- uterine leiomyoma
- leiomyomatosis
- dilated cardiomyopathy
- endometrioma
- metabolic syndrome X
- cardiac hypertrophy
regulates
role in cell
- proliferation
- phosphorylation in
- number
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnni3k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heart rate
- bundle of His cardiac muscle cell to Purkinje myocyte communication
- protein phosphorylation
- regulation of cardiac muscle contraction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity