Hadhb Gene Summary [Rat]
Enables acetyl-CoA C-acyltransferase activity. Involved in fatty acid beta-oxidation. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency 2. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hadhb |
| Official Name | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [Source:RGD Symbol;Acc:620513] |
| Ensembl ID | ENSRNOG00000010800 |
| Bio databases IDs | |
| Aliases | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
| Synonyms | 3-Ketoacyl-CoA Thiolase, 3-Ketoacyl-CoA Thiolase B, 4930479F15Rik, A hydratase (trifunctional protein), beta subunit, A hydratase (trifunctional protein), β subunit, ECHB, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit β, Kat, LKAT, Long-chain 3-ketoacyl-CoA thiolase, Mitochondrial long chain 3-ketoacyl-CoA thiolase, MSTP029, MTPB, MTPD, MTPD2, TP-BETA, TP-β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hadhb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- 3-hydroxyacyl-CoA dehydrogenase
- acetyl-CoA acetyltransferases
- acetyl-CoA C-acetyltransferase
- enzyme
- protein binding
- Beta-ketoacyl synthase, C-terminal domain
- RNA binding
- enoyl-CoA hydratase
- cond_enzymes
- acetyl-CoA C-acyltransferase
- binding protein
- Thiolase, C-terminal domain
Pathways
Biological processes and signaling networks where the Hadhb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- mitochondrial trifunctional protein deficiency
- Huntington disease
- mitochondrial trifunctional protein deficiency type 2
- mitochondrial trifunctional protein deficiency type 1
- liver cancer
- hepatocellular carcinoma
- HADHA-related disorder
- mitochondrial trifunctional protein deficiency type 2 with myopathy and neuropathy
role in cell
- expression in
- formation
- phosphorylation in
- migration
- growth
- invasion by
- thiolysis in
- polymerization in
- response
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- mitochondrial envelope
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
- nucleoplasm
- nucleoli
- nuclear speckles
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hadhb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- cellular response to lipopolysaccharide
- gene expression
Cellular Component
Where in the cell the gene product is active
- mitochondrial fatty acid beta-oxidation multienzyme complex
- mitochondrion
- endoplasmic reticulum
- mitochondrial outer membrane
- mitochondrial envelope
- mitochondrial inner membrane
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA C-acetyltransferase activity
- protein binding
- RNA binding
- acetyl-CoA C-acyltransferase activity
- 3-hydroxyacyl-CoA dehydrogenase activity
- enoyl-CoA hydratase activity
- acetyl-CoA C-myristoyltransferase activity