Actc1 Gene Summary [Rat]
Predicted to enable ATP binding activity; microfilament motor activity; and myosin binding activity. Involved in cardiac muscle contraction; response to ethanol; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including I band; filopodium; and lamellipodium. Predicted to be part of protein-containing complex. Predicted to be active in actin filament; glutamatergic synapse; and sarcomere. Biomarker of hypertension. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actc1 |
| Official Name | actin, alpha, cardiac muscle 1 [Source:RGD Symbol;Acc:2026] |
| Ensembl ID | ENSRNOG00000008536 |
| Bio databases IDs | |
| Aliases | actin, alpha, cardiac muscle 1 |
| Synonyms | ACTC, actin alpha cardiac muscle 1, actin, alpha, cardiac muscle 1, actin α cardiac muscle 1, actin, α, cardiac muscle 1, alpha-cardiac actin, ASD5, Cardiac α Actin, CMD1R, CMH11, LVNC4, α-cardiac actin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Actc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- Actin
- ATP binding
- microfilament motor protein
- enzyme
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Actc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Calcium Signaling
- Caveolar-mediated Endocytosis Signaling
- Cellular Effects of Sildenafil (Viagra)
- Clathrin-mediated Endocytosis Signaling
- Death Receptor Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gap Junction Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- ILK Signaling
- Leukocyte Extravasation Signaling
- Mechanisms of Viral Exit from Host Cells
- MSP-RON Signaling Pathway
- NRF2-mediated Oxidative Stress Response
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- TEC Kinase Signaling
- Tight Junction Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- familial hypertrophic cardiomyopathy
- familial hypertrophic cardiomyopathy-11
- dilated cardiomyopathy 1R
- prostate cancer
- uterine leiomyoma
- leiomyomatosis
- chronic sinusitis
- dilated cardiomyopathy
- hereditary disorder
role in cell
- apoptosis
- abnormal morphology
- disarray
- assembly
- structural integrity
- replication in
- breakage in
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cellular membrane
- Nucleus
- myofilaments
- actin filaments
- sarcomere
- cytosol
- synapse
- I band
- filopodia
- perikaryon
- exosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Actc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart contraction
- actin-myosin filament sliding
- actomyosin structure organization
- negative regulation of apoptotic process
- positive regulation of gene expression
- skeletal muscle thin filament assembly
- mesenchyme migration
- cardiac myofibril assembly
- actin filament organization
- actin filament-based movement
- cardiac muscle tissue morphogenesis
Cellular Component
Where in the cell the gene product is active
- actin filament
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- blood microparticle
- cell body
- actin cytoskeleton
- cytosol
- filopodium
- I band
- sarcomere
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- myosin binding
- microfilament motor activity
- hydrolase activity