Ush1g Gene Summary [Rat]
Predicted to enable identical protein binding activity and spectrin binding activity. Predicted to be involved in several processes, including photoreceptor cell maintenance; regulation of clathrin-dependent endocytosis; and sensory perception of sound. Predicted to act upstream of or within inner ear morphogenesis and inner ear receptor cell stereocilium organization. Predicted to be located in several cellular components, including ciliary base; cytoskeleton; and nuclear body. Human ortholog(s) of this gene implicated in Usher syndrome type 1G. Orthologous to human USH1G (USH1 protein network component sans). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ush1g |
| Official Name | USH1 protein network component sans [Source:RGD Symbol;Acc:1304551] |
| Ensembl ID | ENSRNOG00000028456 |
| Bio databases IDs | |
| Aliases | USH1 protein network component sans |
| Synonyms | ANKS4A, js, SANS, USH1 protein network component sans |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ush1g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- Ankyrin repeats (many copies)
- SAM (Sterile alpha motif )
- SAM domain
- Ankyrin repeats (3 copies)
- spectrin binding
- CEN_USH1G_ANKS4B
- protein binding
- identical protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Usher syndrome type 1G
- colorectal cancer
- Usher syndrome
- hearing loss
- familial nonsyndromic hearing impairment
- autosomal recessive deafness
- Usher syndrome type 1
- androgenic alopecia
regulated by
- MYO7A
- P-TEFb
role in cell
- differentiation
- abnormal morphology
- organization
- mechanotransduction
- maintenance
- disorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- cellular membrane
- actin cytoskeleton
- basal bodies
- cytosol
- connecting cilia
- nuclear speckles
- Cajal bodies
- neurites
- photoreceptor inner segments
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ush1g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- inner ear receptor stereocilium organization
- photoreceptor cell maintenance
- inner ear morphogenesis
- equilibrioception
- sensory perception of light stimulus
- regulation of clathrin-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- centrosome
- cilium basal body
- nuclear speck
- Cajal body
- actin cytoskeleton
- cytosol
- photoreceptor inner segment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- spectrin binding