Htra2 Gene Summary [Rat]
Enables serine-type peptidase activity. Involved in several processes, including ceramide metabolic process; pentacyclic triterpenoid metabolic process; and response to herbicide. Predicted to be located in several cellular components, including chromatin; cytoplasmic side of plasma membrane; and mitochondrial intermembrane space. Predicted to be part of CD40 receptor complex and serine-type endopeptidase complex. Predicted to be active in mitochondrion. Used to study transient cerebral ischemia. Biomarker of asphyxia neonatorum; cryptorchidism; middle cerebral artery infarction; and status epilepticus. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htra2 |
| Official Name | HtrA serine peptidase 2 [Source:RGD Symbol;Acc:1308906] |
| Ensembl ID | ENSRNOG00000022448 |
| Bio databases IDs | |
| Aliases | HtrA serine peptidase 2 |
| Synonyms | HtrA serine peptidase 2, MGCA8, mnd2, OMI, PARK13, PRSS25 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Htra2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- Tryp_SPc
- catalytic domain
- peptidase
- enzyme inhibitor activity
- canonical PDZ domain
- enzyme
- enzyme regulator activity
- protein binding
- PDZ domain
- cleavage site
- identical protein binding
- IAP binding domain
- protein serine/threonine kinase inhibitor
- serine endopeptidase
- serine-type peptidase
- active site
- Trypsin-like peptidase domain
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Htra2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- 3-methylglutaconic aciduria type 8
- growth failure
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- ataxia
- Parkinson disease type 13
- akinesia
- muscle weakness
- lack of spontaneous movement
role in cell
- number
- cell death
- expression in
- activation in
- loss
- apoptosis
- production in
- degradation in
- molecular cleavage in
- excitotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- mitochondrial fraction
- cytoskeleton
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum membrane
- mitochondrial intermembrane space
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Htra2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- negative regulation of cell cycle
- execution phase of apoptosis
- positive regulation of execution phase of apoptosis
- response to herbicide
- negative regulation of neuron apoptotic process
- adult walking behavior
- cellular response to heat
- forebrain development
- pentacyclic triterpenoid metabolic process
- intracellular signal transduction
- neuron apoptotic process
- cellular response to interferon-beta
- mitochondrial protein catabolic process
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- protein catabolic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- ceramide metabolic process
- neuron development
- mitochondrion organization
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- cellular response to retinoic acid
- cellular response to growth factor stimulus
- positive regulation of apoptotic process
- proteolysis
- cellular response to oxidative stress
- protein autoprocessing
- programmed cell death
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- chromatin
- internal side of plasma membrane
- endoplasmic reticulum membrane
- nucleus
- mitochondrial intermembrane space
- mitochondrial membrane
- cytoskeleton
- mitochondrion
- membrane
- cytosol
- CD40 receptor complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein serine/threonine kinase inhibitor activity
- protein binding
- serine-type endopeptidase activity
- serine-type peptidase activity
- unfolded protein binding
- peptidase activity