NEWGENE_1308171 Gene Summary [Rat]
Predicted to enable growth factor activity. Involved in negative regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular matrix. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | NEWGENE_1308171 |
| Official Name | osteoglycin [Source:RGD Symbol;Acc:11378586] |
| Ensembl ID | ENSRNOG00000029792 |
| Bio databases IDs | |
| Aliases | osteoglycin |
| Synonyms | 3110079A16Rik, mimecan, mimican, NEWGENE 1308171, OG, OIF, osteoglycin, SLRR3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Newgene_1308171 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat
- protein binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- androgenic alopecia
- osteoarthritis
- gastric cancer
- uterine leiomyoma
- leiomyomatosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- chronic sinusitis
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- abnormal morphology
- mineralization by
- fibrillogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Endoplasmic Reticulum
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Newgene_1308171 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of smooth muscle cell proliferation
- bone development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- lysosomal lumen
- extracellular matrix
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- extracellular matrix structural constituent conferring compression resistance