Ogn Gene Summary [Mouse]
Predicted to enable growth factor activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in articular cartilage development; bone development; and negative regulation of smooth muscle cell proliferation. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and skeleton. Orthologous to human OGN (osteoglycin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ogn |
| Official Name | osteoglycin [Source:MGI Symbol;Acc:MGI:109278] |
| Ensembl ID | ENSMUSG00000021390 |
| Bio databases IDs | |
| Aliases | osteoglycin |
| Synonyms | 3110079A16Rik, mimecan, mimican, NEWGENE 1308171, OG, OIF, osteoglycin, SLRR3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ogn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat
- protein binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- androgenic alopecia
- osteoarthritis
- gastric cancer
- uterine leiomyoma
- leiomyomatosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- chronic sinusitis
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- abnormal morphology
- mineralization by
- fibrillogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Endoplasmic Reticulum
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ogn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of smooth muscle cell proliferation
- bone development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- lysosomal lumen
- extracellular matrix
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- extracellular matrix structural constituent conferring compression resistance