OGN Gene Summary [Human]
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | OGN |
| Official Name | osteoglycin [Source:HGNC Symbol;Acc:HGNC:8126] |
| Ensembl ID | ENSG00000106809 |
| Bio databases IDs | |
| Aliases | osteoglycin, mimecan proteoglycan |
| Synonyms | 3110079A16Rik, mimecan, mimican, NEWGENE 1308171, OG, OIF, osteoglycin, SLRR3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OGN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat
- protein binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- androgenic alopecia
- osteoarthritis
- gastric cancer
- uterine leiomyoma
- leiomyomatosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- chronic sinusitis
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- abnormal morphology
- mineralization by
- fibrillogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Endoplasmic Reticulum
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OGN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of smooth muscle cell proliferation
- bone development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- lysosomal lumen
- extracellular matrix
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- extracellular matrix structural constituent conferring compression resistance