Mt-nd5 Gene Summary [Rat]
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Part of mitochondrial respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Mt-nd5 |
| Official Name | mitochondrially encoded NADH dehydrogenase 5 [Source:RGD Symbol;Acc:620560] |
| Ensembl ID | ENSRNOG00000029971 |
| Bio databases IDs | |
| Aliases | mitochondrially encoded NADH dehydrogenase 5 |
| Synonyms | 0610010I05RIK, Nadh5, NADH dehydrogenase subunit 5, ND5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mt-Nd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
- proton-translocating NADH-quinone oxidoreductase, chain L
- Proton-conducting membrane transporter
- enzyme
- NADH2 dehydrogenase (ubiquinone)
- NADH dehydrogenase subunit 5 C-terminus
Pathways
Biological processes and signaling networks where the Mt-Nd5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- breast carcinoma
- Leber optic atrophy
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- MELAS syndrome
- hyperplastic thyroid nodule
- colorectal cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
role in cell
- activation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mt-Nd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- electron transport coupled proton transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- response to hydrogen peroxide
- aerobic respiration
- response to organic nitrogen
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase activity
- NADH dehydrogenase (ubiquinone) activity