Slc25a5 Gene Summary [Rat]
Predicted to enable several functions, including ATP:ADP antiporter activity; oxidative phosphorylation uncoupler activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including hemopoiesis; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and nucleotide transmembrane transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in membrane raft and mitochondrial inner membrane. Orthologous to human SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a5 |
| Official Name | solute carrier family 25 member 5 [Source:RGD Symbol;Acc:620353] |
| Ensembl ID | ENSRNOG00000039980 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 5 |
| Synonyms | 2F1, AAC2, Adenine nucleotide translocator 2, Adp, atp carrier, ADP/ATP CARRIER, ADT2, ANC2, ANT2, Fibroblast ATP/ADP Carrier, Slc25a6, solute carrier family 25 member 5, solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5, T2, T3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc25a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- ubiquitin protein ligase binding
- adenine nucleotide transporter
- Mitochondrial carrier protein
- protein binding
- ATP/ADP antiporter
- adenine transporter
- transporter
- oxidative phosphorylation uncoupler
Pathways
Biological processes and signaling networks where the Slc25a5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial infarction
- prostate cancer
- depressive disorder
- epithelial cancer
- breast cancer
- gout
- sickle cell anemia
- pain
- knee osteoarthritis
- psoriasis
role in cell
- expression in
- apoptosis
- consumption in
- cell death
- morphology
- activation
- proliferation
- binding in
- differentiation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- mitochondrial envelope
- cellular membrane
- inner membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- mitochondrial nucleoids
- mitochondrial inner membrane
- nuclear scaffolds
- membrane rafts
- perinuclear focus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc25a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte differentiation
- B cell differentiation
- positive regulation of cell proliferation
- chromosome segregation
- adenine nucleotide transport
- regulation of mitochondrial membrane permeability
- adenine transport
Cellular Component
Where in the cell the gene product is active
- MMXD complex
- nucleus
- mitochondrial permeability transition pore complex
- mitochondrion
- membrane
- plasma membrane
- mitochondrial inner membrane
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- RNA binding
- adenine nucleotide transmembrane transporter activity
- ubiquitin protein ligase binding
- protein binding
- hydrogen ion transmembrane transporter activity
- ATP:ADP antiporter activity
- oxidative phosphorylation uncoupler activity
- adenine transmembrane transporter activity