Pdp1 Gene Summary [Rat]
Enables calcium ion binding activity; magnesium ion binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and signal transduction. Located in mitochondrion. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdp1 |
| Official Name | pyruvate dehyrogenase phosphatase catalytic subunit 1 [Source:RGD Symbol;Acc:620393] |
| Ensembl ID | ENSRNOG00000016180 |
| Bio databases IDs | |
| Aliases | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
| Synonyms | Gm1024, PDH, PDP, Pdp1c, PDPC, PDPC 1, PPM2A, PPM2C, PYRUVATE DEHYDROGENASE, Pyruvate Dehydrogenase Phosphatase 1, pyruvate dehydrogenase phosphatase catalytic subunit 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein serine/threonine phosphatase
- [pyruvate dehydrogenase (lipoamide)]-phosphatase
- phosphatase
- calcium ion binding
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- magnesium ion binding
- PP2Cc
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- lung adenocarcinoma
- bipolar disorder
- Alzheimer disease
- septic shock
- lung squamous cell carcinoma
- squamous cell lung cancer
- refractory acute myeloid leukemia
- Huntington disease
role in cell
- proliferation
- growth
- growth in
- survival
- quizartinib sensitivity
- mitochondrial respiration in
- oxidative phosphorylation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- pyruvate dehydrogenase (lipoamide) phosphatase complex
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
- [pyruvate dehydrogenase (lipoamide)] phosphatase activity