Vps13c Gene Summary [Rat]
Predicted to be involved in mitochondrion organization; negative regulation of type 2 mitophagy; and protein localization to organelle. Predicted to act upstream of or within response to insulin. Predicted to be located in several cellular components, including cytoplasmic vesicle; lipid droplet; and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Parkinson's disease 23. Orthologous to human VPS13C (vacuolar protein sorting 13 homolog C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps13c |
| Official Name | vacuolar protein sorting 13 homolog C [Source:RGD Symbol;Acc:1560364] |
| Ensembl ID | ENSRNOG00000030213 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 13 homolog C |
| Synonyms | AI552542, AV026040, BLTP5C, C230055H22RIK, chorein, FLJ20136, PARK23, RGD1560364, vacuolar protein sorting 13C, vacuolar protein sorting 13 homolog C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vps13c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SHR-binding domain of vacuolar-sorting associated protein 13
- Vacuolar-sorting-associated 13 protein C-terminal
- N-terminal region of Chorein or VPS13
- Repeating coiled region of VPS13
- Vacuolar sorting-associated protein 13, N-terminal
- Autophagy-related protein C terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive early-onset parkinson disease 23
- early-onset Parkinson disease
- metabolic syndrome X
- Parkinson disease
- non-insulin-dependent diabetes mellitus
regulates
- D-glucose
role in cell
- organization
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- secretory granule membrane
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vps13c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein retention in Golgi apparatus
- lipid transport
- response to insulin stimulus
- protein targeting to vacuole
- Golgi to endosome transport
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- late endosome membrane
- extracellular vesicular exosome
- cytoplasm
- late endosome
- cytosol
- mitochondrial outer membrane
- lysosomal membrane
- dense core granule membrane
- lysosome