Nucb2 Gene Summary [Rat]
Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Located in Golgi medial cisterna and extracellular space. Biomarker of alcohol dependence; obesity; and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nucb2 |
| Official Name | nucleobindin 2 [Source:RGD Symbol;Acc:620888] |
| Ensembl ID | ENSRNOG00000020456 |
| Bio databases IDs | |
| Aliases | nucleobindin 2 |
| Synonyms | Calnuc, HEL-S-109, LOC105376575, Nef, NEFA, Nesfatin-1, nucleobindin 2, p54 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nucb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- tumor necrosis factor receptor binding
- EF-hand domain pair
- guanyl-nucleotide exchange factor
- calcium ion binding
- EFh
- protein binding
- helix-loop-helix domain
- acidic domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- ulcerative colitis
- inflammatory bowel disease
- insomnia
- schizophrenia
- Waldenström macroglobulinemia
- organismal death
- weight gain
- preeclampsia
- lung adenocarcinoma
role in cell
- expression in
- differentiation
- proliferation
- phosphorylation in
- migration
- activation
- invasion by
- homeostasis in
- inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- mitochondrial fraction
- Cytoplasm
- Extracellular Space
- cell periphery
- perinuclear region
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- outer nuclear membrane
- nuclear envelope
- Golgi cisternae
- perikaryon
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nucb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- sequestering of metal ion
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- extracellular space
- extracellular vesicular exosome
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- G-protein alpha-subunit binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity