FNDC5 Gene Summary [Human]
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Details
| Type | Processed Transcript |
| Official Symbol | FNDC5 |
| Official Name | fibronectin type III domain containing 5 [Source:HGNC Symbol;Acc:HGNC:20240] |
| Ensembl ID | ENSG00000160097 |
| Bio databases IDs | |
| Aliases | fibronectin type III domain containing 5, irisin |
| Synonyms | 1500001L03Rik, D1MGI29, fibronectin type III domain containing 5, FRCP2, irisin, LOC260327, PeP, PXP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FNDC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- albuminuria
- diabetes mellitus
- preeclampsia
- high-fat diet-induced obesity
- motor dysfunction
- Alzheimer disease
- end stage renal disease
- intrauterine growth retardation
- interstitial fibrosis
- osteolysis
role in cell
- expression in
- apoptosis
- cell death
- migration
- production in
- proliferation
- quantity
- invasion by
- morphology
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FNDC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- positive regulation of brown fat cell differentiation
- signal transduction
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- hormone activity