Slco1b2 Gene Summary [Rat]
Enables bile acid transmembrane transporter activity and oligopeptide transmembrane transporter activity. Involved in several processes, including bile acid and bile salt transport; response to glucocorticoid; and response to lipopolysaccharide. Located in basolateral plasma membrane. Used to study bilirubin metabolic disorder. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder and gastrointestinal stromal tumor. Orthologous to several human genes including SLCO1B3 (solute carrier organic anion transporter family member 1B3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slco1b2 |
| Official Name | solute carrier organic anion transporter family, member 1B2 [Source:RGD Symbol;Acc:69300] |
| Ensembl ID | ENSRNOG00000030538 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 1B2 |
| Synonyms | 7330442B20RIK, HBLRR, lst-1, LST-2, LST3, LST-3TM13, mlst-1, OATP1B2, OATP1B3, OATP2, OATP-4, OATP8, OATP-C, rlst-1, SLC21A10, Slc21a6, SLC21A8, Slco1b, SLCO1B2, solute carrier organic anion transporter family member 1B2, solute carrier organic anion transporter family, member 1b2, solute carrier organic anion transporter family member 1B3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slco1b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- amide transporter
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- bile acid transporter
- KAZAL_FS
- organic anion transporter
- prostaglandin transporter
- transporter
Pathways
Biological processes and signaling networks where the Slco1b2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colon cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- prostatic adenocarcinoma
- prostate cancer
- liver cancer
- cholestasis
role in cell
- apoptosis
- survival
- binding in
- accumulation in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane vesicles
- membrane fraction
- Cytoplasm
- intracellular space
- cellular membrane
- basolateral cell surfaces
- basolateral membrane
- basal membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slco1b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- sodium-independent organic anion transport
- xenobiotic metabolic process
- heme catabolic process
- organic anion transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid transmembrane transporter activity
- serine-type endopeptidase inhibitor activity
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity