Nhs Gene Summary [Rat]

Predicted to be involved in cell differentiation and lens development in camera-type eye. Predicted to be located in Golgi apparatus; cell junction; and nuclear body. Human ortholog(s) of this gene implicated in Nance-Horan syndrome and cataract 40. Orthologous to human NHS (NHS actin remodeling regulator). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Nhs
Official Name
NHS actin remodeling regulator [Source:RGD Symbol;Acc:1561818]
Ensembl ID
ENSRNOG00000030759
Bio databases IDs NCBI: 317494 Ensembl: ENSRNOG00000030759
Aliases NHS actin remodeling regulator
Synonyms CCT, CTRCT40, CXN, FLJ22511, Gm389, Gm48, Nhs1, NHS actin remodeling regulator, RGD1561818, SCML1, Xcat
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nhs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WAVE homology domain
  • NHS-like

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • Nance-Horan syndrome
  • keratocystic odontogenic tumor
  • keratocystic odontogenic tumors
  • hereditary disorder
  • cataract 40
  • congenital cataract
  • Wilms tumorigenesis
regulated by
  • dexamethasone
  • filgrastim
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • cell junction
  • Golgi Apparatus
  • nuclear bodies

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Nhs gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell differentiation
  • lens development in camera-type eye

Cellular Component

Where in the cell the gene product is active
  • tight junction
  • nuclear body
  • focal adhesion
  • cell junction
  • Golgi apparatus
  • apical plasma membrane
  • lamellipodium

Gene-Specific Assays for Results You Can Trust

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