Nprl2 Gene Summary [Rat]
Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and negative regulation of kinase activity. Predicted to be part of GATOR1 complex. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 2. Orthologous to human NPRL2 (NPR2 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nprl2 |
| Official Name | NPR2-like, GATOR1 complex subunit [Source:RGD Symbol;Acc:1308927] |
| Ensembl ID | ENSRNOG00000021660 |
| Bio databases IDs | |
| Aliases | NPR2-like, GATOR1 complex subunit |
| Synonyms | 2810446G01Rik, FFEVF2, G21, NPR2, NPR2L, NPR2-like, GATOR1 complex subunit, TUSC4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nprl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nitrogen Permease regulator of amino acid transport activity 3
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- hereditary disorder
- familial focal epilepsy with variable foci type 2
- anophthalmia
- estrogen receptor positive HER2 negative PIK3CA mutation positive breast cancer
- localization-related epilepsy
- familial focal epilepsy with variable foci
- microphthalmia
regulates
- MTORC1
- HAMP
- S6K1
role in cell
- phosphorylation in
- capivasertib resistance
- number
- response by
- signaling in
- taselisib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nprl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- cellular response to amino acid starvation
- negative regulation of kinase activity
Cellular Component
Where in the cell the gene product is active
- vacuolar membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity