Otud5 Gene Summary [Rat]
Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of TOR signaling; and protein deubiquitination. Predicted to act upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Predicted to be located in nucleus. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otud5 |
| Official Name | OTU deubiquitinase 5 [Source:RGD Symbol;Acc:1563027] |
| Ensembl ID | ENSRNOG00000008764 |
| Bio databases IDs | |
| Aliases | OTU deubiquitinase 5 |
| Synonyms | BB114028, DKFZp761A052, DUBA, DXImx46e, MCAND, OTU deubiquitinase 5, OTU domain containing 5, Sfc7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Otud5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin binding domain
- ubiquitin-specific protease
- enzyme
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute kidney injury
- X-linked multiple congenital anomalies-neurodevelopmental syndrome
- hereditary disorder
- neurodegeneration with brain iron accumulation type 5
role in cell
- expression in
- migration
- phosphorylation in
- proliferation
- invasion by
- production in
- differentiation
- quantity
- binding in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Otud5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- protein deubiquitination
- negative regulation of type I interferon production
- neural crest cell differentiation
- proteolysis
- response to lipopolysaccharide
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity