Irgm Gene Summary [Rat]
Predicted to enable several functions, including G protein activity; anion binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of organelle organization; positive regulation of protein phosphorylation; and regulation of defense response. Predicted to act upstream of or within cellular response to type II interferon and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and vacuole. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and mitochondrial membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irgm |
| Official Name | immunity-related GTPase M [Source:RGD Symbol;Acc:1305163] |
| Ensembl ID | ENSRNOG00000031138 |
| Bio databases IDs | |
| Aliases | immunity-related GTPase M |
| Synonyms | Ifggd3, Ifi1, Iigp3, Iipg3, immunity-related GTPase family M member 1, immunity-related GTPase M, Irgm, LT629149.9, LT629152.10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Irgm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- phospholipid binding
- protein kinase binding
- small monomeric GTPase
- protein binding activity, bridging
- 50S ribosome-binding GTPase
- GTPase
- protein domain specific binding
- enzyme
- protein kinase activator
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- Interferon-inducible GTPase (IIGP)
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- colitis
- insulin-dependent diabetes mellitus
- lymphomyeloid failure
- dextran sodium sulfate-induced colitis
- early onset hypertension
- hyperplasia
- infection by Trypanosoma cruzi
- infection by Mycobacterium avium
role in cell
- adhesion
- cell death
- apoptosis
- expression in
- quantity
- binding in
- production in
- degradation in
- proliferation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- phagolysosome
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- Golgi membrane
- mitochondrial membrane
- lysosome membrane
- autophagic vacuoles
- late endosomes
- autolysosomes
- phagosomes
- phagocytic cups