Oas2 Gene Summary [Rat]
Predicted to enable 2'-5'-oligoadenylate synthetase activity; ATP binding activity; and double-stranded RNA binding activity. Predicted to be involved in several processes, including innate immune response; interleukin-27-mediated signaling pathway; and positive regulation of cytokine production. Predicted to act upstream of or within RNA catabolic process and response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OAS2 (2'-5'-oligoadenylate synthetase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oas2 |
| Official Name | 2'-5' oligoadenylate synthetase 2 [Source:RGD Symbol;Acc:1359697] |
| Ensembl ID | ENSRNOG00000049282 |
| Bio databases IDs | |
| Aliases | 2'-5' oligoadenylate synthetase 2 |
| Synonyms | 2'5' OLIGOADENYLATE SYNTHETASE2, OAS p69/71 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oas2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- nucleotidyltransferase
- double-stranded RNA binding
- ATP binding
- enzyme
- protein binding
- 2'-5'-oligoadenylate synthetase
Pathways
Biological processes and signaling networks where the Oas2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- immune thrombocytopenia
- asthma
- diabetes mellitus
- systemic lupus erythematosus
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- skin cancer
- pemphigus foliaceus
role in cell
- expression in
- cell death
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Nucleus
- cytosol
- microsomal membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oas2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interferon-beta production
- defense response to virus
- positive regulation of tumor necrosis factor production
- response to virus
- defense response to bacterium
- negative regulation of viral genome replication
- nucleobase-containing compound metabolic process
- interleukin-27-mediated signaling pathway
- type I interferon-mediated signaling pathway
- regulation of ribonuclease activity
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- 2'-5'-oligoadenylate synthetase activity
- protein binding
- metal ion binding
- double-stranded RNA binding