Col16a1 Gene Summary [Rat]
Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion mediated by integrin; integrin activation; and positive regulation of focal adhesion assembly. Predicted to act upstream of or within cellular response to amino acid stimulus. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Orthologous to human COL16A1 (collagen type XVI alpha 1 chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col16a1 |
| Official Name | collagen type XVI alpha 1 chain [Source:RGD Symbol;Acc:1310982] |
| Ensembl ID | ENSRNOG00000031475 |
| Bio databases IDs | |
| Aliases | collagen type XVI alpha 1 chain |
| Synonyms | 2700007F12Rik, 447AA, A530052M23Rik, CA1F, collagen, type XVI, alpha 1, collagen type XVI alpha 1 chain, collagen, type XVI, α 1, collagen type XVI α 1 chain, FP1572 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col16a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LamG
- integrin binding
- Collagen triple helix repeat (20 copies)
- protein binding
Pathways
Biological processes and signaling networks where the Col16a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- glaucoma
- open-angle glaucoma
- Peyronie disease
- Dupuytren contracture
- preeclampsia
- burn
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- thoracic aortic aneurysm
regulates
- Integrin
role in cell
- assembly
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col16a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid stimulus
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- positive regulation of focal adhesion assembly
- extracellular matrix organization
- female pregnancy
- cell adhesion
- integrin activation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- collagen type IX
- extracellular region
- collagen type XVI
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent conferring tensile strength
- integrin binding