Hdac10 Gene Summary [Rat]
Predicted to enable histone deacetylase activity; histone deacetylase binding activity; and zinc ion binding activity. Involved in oligodendrocyte development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdac10 |
| Official Name | histone deacetylase 10 [Source:RGD Symbol;Acc:1305874] |
| Ensembl ID | ENSRNOG00000031915 |
| Bio databases IDs | |
| Aliases | histone deacetylase 10 |
| Synonyms | DJ402G11.7, HD10, histone deacetylase 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hdac10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein deacetylase activity
- transcription regulator
- zinc ion binding
- catalytic domain
- deacetylase motif
- histone deacetylase
- enzyme binding
- histone deacetylase binding
- protein binding
- deacetylase
- Arginase-like and histone-like hydrolases
Pathways
Biological processes and signaling networks where the Hdac10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postmenopausal breast cancer
- metastasis
- metastatic colorectal adenocarcinoma
- non-uveal melanoma
- peripheral T-cell lymphoma
- diffuse large B-cell lymphoma
- natural killer/T-cell lymphoma
- systemic lupus erythematosus
- mammary neoplasm
- colorectal adenocarcinoma
regulated by
- valproic acid
- trichostatin A
- 4-phenylbutyric acid
- vorinostat
- givinostat
- butyric acid
- pyroxamide
- tributyrin
- HG146
- entinostat
role in cell
- expression in
- binding in
- activity
- migration
- growth
- invasion by
- mitotic entry in
- acetylation in
- deacetylation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hdac10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- DNA repair
- negative regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- reciprocal DNA recombination
- positive regulation of mismatch repair
- chromatin organization
- regulation of gene expression, epigenetic
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- acetylputrescine deacetylase activity
- zinc ion binding
- protein binding
- histone deacetylase binding
- histone deacetylase activity
- acetylspermidine deacetylase activity
- deacetylase activity
- protein deacetylase activity
- enzyme binding