HDAC10 Gene Summary [Human]

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Details

Type
Nonsense Mediated Decay
Official Symbol
HDAC10
Official Name
histone deacetylase 10 [Source:HGNC Symbol;Acc:HGNC:18128]
Ensembl ID
ENSG00000100429
Bio databases IDs NCBI: 83933 Ensembl: ENSG00000100429
Aliases histone deacetylase 10
Synonyms DJ402G11.7, HD10, histone deacetylase 10
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HDAC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein deacetylase activity
  • transcription regulator
  • zinc ion binding
  • catalytic domain
  • deacetylase motif
  • histone deacetylase
  • enzyme binding
  • histone deacetylase binding
  • protein binding
  • deacetylase
  • Arginase-like and histone-like hydrolases

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • postmenopausal breast cancer
  • metastasis
  • metastatic colorectal adenocarcinoma
  • non-uveal melanoma
  • peripheral T-cell lymphoma
  • diffuse large B-cell lymphoma
  • natural killer/T-cell lymphoma
  • systemic lupus erythematosus
  • mammary neoplasm
  • colorectal adenocarcinoma
regulated by
  • valproic acid
  • trichostatin A
  • 4-phenylbutyric acid
  • vorinostat
  • givinostat
  • butyric acid
  • pyroxamide
  • tributyrin
  • HG146
  • entinostat
regulates
  • MSH2
  • histone
  • NR4A1
  • TXNIP
  • MMP9
  • cytochrome C
  • DNA promoter
  • DNA endogenous promoter
  • RNA polymerase II
  • reporter gene
role in cell
  • expression in
  • binding in
  • activity
  • migration
  • growth
  • invasion by
  • mitotic entry in
  • acetylation in
  • deacetylation in
  • accumulation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • intracellular membrane-bounded organelle
  • Cytoplasm
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human HDAC10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of transcription from RNA polymerase II promoter
  • DNA repair
  • negative regulation of transcription, DNA-dependent
  • regulation of transcription, DNA-dependent
  • reciprocal DNA recombination
  • positive regulation of mismatch repair
  • chromatin organization
  • regulation of gene expression, epigenetic
  • macroautophagy

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • intracellular membrane-bounded organelle
  • cytosol
  • histone deacetylase complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • acetylputrescine deacetylase activity
  • zinc ion binding
  • protein binding
  • histone deacetylase binding
  • histone deacetylase activity
  • acetylspermidine deacetylase activity
  • deacetylase activity
  • protein deacetylase activity
  • enzyme binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.