RT1-Bb Gene Summary [Rat]
Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to morphine; and negative regulation of T cell proliferation. Located in cell surface. Used to study uveitis. Biomarker of pneumocystosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | RT1-Bb |
| Official Name | RT1 class II, locus Bb [Source:RGD Symbol;Acc:3469] |
| Ensembl ID | ENSRNOG00000032708 |
| Bio databases IDs | |
| Aliases | RT1 class II, locus Bb |
| Synonyms | Ab, Abeta, Bb, H-2Ab, histocompatibility 2, class II antigen A, beta 1, histocompatibility 2, class II antigen A, β 1, HLA-DQB1, Ia-2, IAb, I-Abeta, Mhc2 beta, Mhc2 β, Mhc class ii beta, Mhc class ii β, Mhc ii iA, Mhc ii i-ad, Rmcs1, RT1.B, RT1-Bb, RT1 class II, locus Bb |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rt1-Bb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- binding protein
- antigen binding domain
- immunoglobulin domain
- protein binding
- peptide antigen binding
- Class II histocompatibility antigen, beta domain
Pathways
Biological processes and signaling networks where the Rt1-Bb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- rheumatoid arthritis
- insulitis
- Huntington disease
- experimental autoimmune encephalomyelitis
- viremia
- insulin-dependent diabetes mellitus
- dextran sodium sulfate-induced colitis
- growth failure
phenotypes
- Addison's disease
- Aspirin-Induced Asthma
- Autoimmune Diseases
- Behcet's disease
- Cataplexy
- Delayed Hypersensitivity
- Experimental Autoimmune Encephalomyelitis
- Graves Disease
- Hashimoto Disease
- Helicobacter Infections
- Hepatitis B Chronic
- Idiopathic Hypersomnolence
- Nasal Polyps
- Plasmodium falciparum malaria
- Recurrent Respiratory Papillomatosis
- Rhinosinusitis Allergic Fungal
- seasonal allergic rhinitis
- Sjogren's Syndrome
- Sleep Initiation and Maintenance Disorders
- Stevens-Johnson Syndrome
- Stroke
- Transplant Rejection
- Tubulointerstitial Nephritis and Uveitis
- Veno-Occlusive Disease
- Vogt-Koyanagi-Harada disease
- achalasia
- acute disseminated encephalomyelitis
- acute myeloid leukemia
- Agranulocytosis
- allergic hypersensitivity disease
- Alopecia Areata
- ankylosing spondylitis
- Antiphospholipid Syndrome
- aplastic anemia
- Arthritis
- asthma
- atrophic gastritis
- autoimmune hepatitis
- autoimmune pancreatitis
- autoimmune polyendocrine syndrome
- autoimmune polyendocrine syndrome type 2
- autoimmune thrombocytopenic purpura
- autoimmune thyroiditis
- bacterial infectious disease
- beta thalassemia
- Celiac Disease
- cervical dystonia
- choreatic disease
- chronic myeloid leukemia
- cicatricial pemphigoid
- Common Variable Immunodeficiency
- degenerative myopia
- Diabetic Retinopathy
- dilated cardiomyopathy
- dilated cardiomyopathy 1H
- Erythema Multiforme
- glaucoma
- Hepatitis C
- human immunodeficiency virus infectious disease
- Hyperthyroidism
- Hypothyroidism
- immunoglobulin alpha deficiency
- Iridocyclitis
- juvenile rheumatoid arthritis
- latex allergy
- marginal zone B-cell lymphoma
- multidrug-resistant tuberculosis
- Multiple Sclerosis
- Myasthenia Gravis
- Mycosis Fungoides
- Myocarditis
- Myositis
- Narcolepsy
- Neuromyelitis Optica
- Optic Neuritis
- Osteomyelitis
- paroxysmal nocturnal hemoglobinuria
- Pemphigus
- Pneumoconiosis
- pneumocystosis
- precursor lymphoblastic lymphoma/leukemia
- primary progressive multiple sclerosis
- psoriasis
- pulmonary tuberculosis
- pure red-cell aplasia
- Rheumatic Fever
- Rheumatic Heart Disease
- rheumatoid arthritis
- Rhinitis
- Rhinoscleroma
- Sarcoidosis
- sickle cell anemia
- stomach disease
- systemic lupus erythematosus
- thrombotic thrombocytopenic purpura
- type 1 diabetes mellitus
- Uveitis
- Vitiligo
- Small Fiber Neuropathy
- Crohn's disease
- Drug-induced Neutropenia
- colorectal cancer
- dental caries
- Hepatitis B
- hepatocellular carcinoma
- pemphigus vulgaris
- primary sclerosing cholangitis
- ulcerative colitis
- Chronic Hepatitis B
- acute lymphoblastic leukemia
- Amebic Liver Abscess
- Chronic Hepatitis C
- End Stage Liver Disease
- Uterine Cervical Dysplasia
- allergic bronchopulmonary aspergillosis
- alveolar echinococcosis
- aspirin-induced respiratory disease
- autoimmune disease
- cervical cancer
- chikungunya
- common wart
- cystic echinococcosis
- Liver Cirrhosis
- Pre-Eclampsia
- Silicosis
- tropical spastic paraparesis
- Tuberculosis
- Typhoid Fever
- vulva cancer
role in cell
- expression in
- growth
- proliferation
- number
- function
- activation
- production in
- quantity
- migration
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- endosomes
- Golgi Apparatus
- plasma membrane extracellular face
- early endosomes
- multivesicular bodies
- exosomes