H2-Ab1 Gene Summary [Mouse]
Enables peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and immune response. Located in Golgi apparatus; endosome; and external side of plasma membrane. Part of MHC class II protein complex. Is expressed in several structures, including adipose tissue; bone; hemolymphoid system; liver; and lung. Used to study dilated cardiomyopathy and myocarditis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | H2-Ab1 |
| Official Name | histocompatibility 2, class II antigen A, beta 1 [Source:MGI Symbol;Acc:MGI:103070] |
| Ensembl ID | ENSMUSG00000073421 |
| Bio databases IDs | |
| Aliases | histocompatibility 2, class II antigen A, beta 1 |
| Synonyms | Ab, Abeta, Bb, H-2Ab, histocompatibility 2, class II antigen A, beta 1, histocompatibility 2, class II antigen A, β 1, HLA-DQB1, Ia-2, IAb, I-Abeta, Mhc2 beta, Mhc2 β, Mhc class ii beta, Mhc class ii β, Mhc ii iA, Mhc ii i-ad, Rmcs1, RT1.B, RT1-Bb, RT1 class II, locus Bb |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2-Ab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- binding protein
- antigen binding domain
- immunoglobulin domain
- protein binding
- peptide antigen binding
- Class II histocompatibility antigen, beta domain
Pathways
Biological processes and signaling networks where the H2-Ab1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- rheumatoid arthritis
- insulitis
- Huntington disease
- experimental autoimmune encephalomyelitis
- viremia
- insulin-dependent diabetes mellitus
- dextran sodium sulfate-induced colitis
- growth failure
role in cell
- expression in
- growth
- proliferation
- number
- function
- activation
- production in
- quantity
- migration
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- endosomes
- Golgi Apparatus
- plasma membrane extracellular face
- early endosomes
- multivesicular bodies
- exosomes