Zrsr2 Gene Summary [Rat]
Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Predicted to be involved in spliceosomal complex assembly. Predicted to be located in nucleolus. Predicted to be part of U12-type spliceosomal complex and U2AF complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zrsr2 |
| Official Name | zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 [Source:RGD Symbol;Acc:1559763] |
| Ensembl ID | ENSRNOG00000033176 |
| Bio databases IDs | |
| Aliases | zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 |
| Synonyms | 5031411E02Rik, A230052C13Rik, OFD21, RGD1559763, U2AF1L2, U2AF1-RS2, URP, ZC3H22, zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zrsr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- pre-mRNA 3' splice site binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- myelodysplastic syndrome with isolated del(5q)
- acute myeloid leukemia
- malignant hematopoietic neoplasm
- hematologic cancer
- myelodysplastic syndrome
- blastic plasmacytoid dendritic cell neoplasm
- myeloid neoplasia
- plasma cell myeloma
- orofaciodigital syndrome xxi
role in cell
- differentiation
- assembly
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zrsr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- U12-type spliceosomal complex
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- pre-mRNA 3'-splice site binding
- metal ion binding