ZRSR2 Gene Summary [Human]
This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZRSR2 |
| Official Name | zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 [Source:HGNC Symbol;Acc:HGNC:23019] |
| Ensembl ID | ENSG00000169249 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 |
| Synonyms | 5031411E02Rik, A230052C13Rik, OFD21, RGD1559763, U2AF1L2, U2AF1-RS2, URP, ZC3H22, zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZRSR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- pre-mRNA 3' splice site binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- myelodysplastic syndrome with isolated del(5q)
- acute myeloid leukemia
- malignant hematopoietic neoplasm
- hematologic cancer
- myelodysplastic syndrome
- blastic plasmacytoid dendritic cell neoplasm
- myeloid neoplasia
- plasma cell myeloma
- orofaciodigital syndrome xxi
role in cell
- differentiation
- assembly
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZRSR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- U12-type spliceosomal complex
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- pre-mRNA 3'-splice site binding
- metal ion binding