LOC108348079 Gene Summary [Rat]
This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | LOC108348079 |
| Official Name | RING finger protein 113A-like [Source:RGD Symbol;Acc:11447433] |
| Ensembl ID | ENSRNOG00000034040 |
| Bio databases IDs | |
| Aliases | RING finger protein 113A-like |
| Synonyms | 2810428C21Rik, Cwc24, LOC108348079, ring finger protein 113A, ring finger protein 113A1, RNF113, Rnf113a1, TTD5, ZINC FINGER protein 183, ZNF183 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348079 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- nonphotosensitive trichothiodystrophy type 5
role in cell
- autophagy in
- splicing by
- focus formation in
- autophagy
- BI-2536 sensitivity
- tanespimycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108348079 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of chemokine-mediated signaling pathway
- snoRNA splicing
- protein ubiquitination
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- U2-type spliceosomal complex
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding