Rnf113a1 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in RNA splicing; negative regulation of chemokine-mediated signaling pathway; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Is expressed in several structures, including ear; nervous system; and urinary system. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 5. Orthologous to human RNF113A (ring finger protein 113A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf113a1 |
| Official Name | ring finger protein 113A1 [Source:MGI Symbol;Acc:MGI:1917192] |
| Ensembl ID | ENSMUSG00000036537 |
| Bio databases IDs | |
| Aliases | ring finger protein 113A1 |
| Synonyms | 2810428C21Rik, Cwc24, LOC108348079, ring finger protein 113A, ring finger protein 113A1, RNF113, Rnf113a1, TTD5, ZINC FINGER protein 183, ZNF183 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf113a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- nonphotosensitive trichothiodystrophy type 5
role in cell
- autophagy in
- splicing by
- focus formation in
- autophagy
- BI-2536 sensitivity
- tanespimycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf113a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of chemokine-mediated signaling pathway
- snoRNA splicing
- protein ubiquitination
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- U2-type spliceosomal complex
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding