Gdpd5 Gene Summary [Rat]
Predicted to enable glycerophosphocholine phosphodiesterase activity and glycerophosphodiester phosphodiesterase activity. Predicted to be involved in positive regulation of cell cycle and positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of Notch signaling pathway; neuron differentiation; and regulation of timing of cell differentiation. Predicted to be located in several cellular components, including axon; neuronal cell body; and perinuclear endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human GDPD5 (glycerophosphodiester phosphodiesterase domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdpd5 |
| Official Name | glycerophosphodiester phosphodiesterase domain containing 5 [Source:RGD Symbol;Acc:1559673] |
| Ensembl ID | ENSRNOG00000036859 |
| Bio databases IDs | |
| Aliases | glycerophosphodiester phosphodiesterase domain containing 5 |
| Synonyms | GDE2, glycerophosphodiester phosphodiesterase domain containing 5, Image 4224574, Image:4224574, PP1665, RGD1559673 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdpd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycerophosphocholine phosphodiesterase
- enzyme
- protein binding
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- glycerophosphodiester phosphodiesterase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- corneal dystrophy
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- acute myeloid leukemia
- coronary artery disease
role in cell
- proliferation
- differentiation
- number
- cell cycle progression
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- reticular perinuclear compartment
- endoplasmic reticulum membrane
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdpd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- nervous system development
- positive regulation of neuron differentiation
Cellular Component
Where in the cell the gene product is active
- growth cone
- perinuclear region of cytoplasm
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- glycerophosphocholine phosphodiesterase activity
- glycerophosphodiester phosphodiesterase activity